the absence or alienation of affection or goodwill; estrangement; disloyalty: Disaffection often leads to outright treason.

1595–1605; dis-1 + affection1

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World English Dictionary
disaffection (ˌdɪsəˈfɛkʃən)
a state of dissatisfaction or alienation: the growing disaffection between players

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Example sentences
It's a breathtaking reversal after decades of disaffection and doubt.
The same goes for the caricature of technology as a civic virus that breeds
  disaffection from politics.
Local disaffection is echoed in some federal agencies.
Both universities offered an opposition to parliamentary government, which
  brought upon them the charge of disaffection.
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