verb (used with object), discombobulated, discombobulating.
to confuse or disconcert; upset; frustrate: The speaker was completely discombobulated by the hecklers.

1825–35, Americanism; fanciful alteration of discompose or discomfort

discombobulation, noun
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World English Dictionary
discombobulate (ˌdɪskəmˈbɒbjʊˌleɪt)
informal chiefly (US), (Canadian) (tr) to throw into confusion
[C20: probably a whimsical alteration of discompose or discomfit]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

1834, Amer.Eng., fanciful coinage of a type popular then (originally discombobricate). Related: discombobulating; discombobulation.
Online Etymology Dictionary, © 2010 Douglas Harper
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