"You canker blossom!" 3 Shakespearean Insults
early 14c., "discomfort, inconvenience," from Old French desaise "lack, want; discomfort, distress; trouble, misfortune; disease, sickness," from des- "without, away" (see dis-) + aise "ease" (see ease). Sense of "sickness, illness" in English first recorded late 14c.; the word still sometimes was used in its literal sense early 17c.
disease dis·ease (dĭ-zēz')
A pathological condition of a body part, an organ, or a system resulting from various causes, such as infection, genetic defect, or environmental stress, and characterized by an identifiable group of signs or symptoms.