gene-amplification

gene amplification

noun Genetics.
1.
an increase in the frequency of replication of a DNA segment.
2.
such an increase induced by a polymerase chain reaction.
Also called genetic amplification, DNA amplification.


Origin:
1970–75

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Based on the Random House Dictionary, © Random House, Inc. 2014.
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American Heritage
Medical Dictionary

gene amplification n.
A cellular process characterized by the production of copies of a gene or genes to amplify the phenotype that the gene confers on the cell.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
gene amplification  
An increase in the number of copies of a gene in a cell, resulting in an elevation in the level of the RNA or protein encoded for by the gene and a corresponding amplification of the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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American Heritage
Cultural Dictionary

gene amplification definition


A process in a cell by which a particular gene is replicated so that more copies are available to produce a protein for the cell's use. For example, the genes that code for proteins involved in ribosomes are amplified early in the process of cell development so that there are sufficient numbers of them to assemble the cell.

Note: PCR, polymerase chain reaction, can be considered a type of man-made gene amplification process.
The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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