a daughter of one's son or daughter.

1605–15; grand- + daughter Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
granddaughter (ˈɡrænˌdɔːtə)
a daughter of one's son or daughter

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Example sentences
Beside him was his granddaughter, on her knees and bathed in tears.
The granddaughter was a year old, maybe a little older.
Her husband had gone for water, so she began chopping wood for the cooking
  fire, while her granddaughter watched from the veranda.
Carol's sons have now married and each has given her a granddaughter.
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