hand·cuff

[hand-kuhf]
noun
1.
a ring-shaped metal device that can be locked around a person's wrist, usually one of a pair connected by a short chain or linked bar; shackle: The police put handcuffs on the suspect.
verb (used with object)
2.
to put handcuffs on.
3.
to restrain or thwart (someone) by or as if by handcuffing: The amendments handcuffed the committee and prevented further action.

Origin:
1635–45; hand + cuff1

un·hand·cuff, verb (used with object)
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2013.
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World English Dictionary
handcuff (ˈhændˌkʌf) [Click for IPA pronunciation guide]
 
vb
1.  (tr) to put handcuffs on (a person); manacle
 
n
2.  (plural) a pair of locking metal rings joined by a short bar or chain for securing prisoners, etc

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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00:10
Handcuff is one of our favorite verbs.
So is skedaddle. Does it mean:
to bark; yelp.
to run away hurriedly; flee.
Etymonline
Word Origin & History

handcuff
1775, from hand + cuff. The verb is first attested 1720. O.E. had hondcops "a pair of hand cuffs," but the modern word is a re-invention.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
They would handcuff and blindfold the prisoners before they left the room.
He also admitted that he struggled with the police officers because he did not
  want them to handcuff him.
Then he asked them not to handcuff him, and the request was denied.
So saying, they handcuff him, and carry him away to the regiment.
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