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Determined by innate brain functions; not a matter of choice: These individuals seem hard-wired only to show up at work, do their task and leave with a paycheck/ We're hard-wired to be social creatures
[1970s+; fr the definiteness of an actual wired connection in a computer, as distinct from something depending on a program]
3. By extension, anything that is not modifiable, especially in the sense of customisable to one's particular needs or tastes.