Pit bulls, he says, are hard-wired for aggression and generally do not make safe pets.
Perhaps compose a fiction about hard-wired fictionalizing, a fiction that reminds readers of their synaptic deceptions.
And of course there is the gene, that hard-wired Calvinist gateway to gloomy fate.
Determined by innate brain functions; not a matter of choice: These individuals seem hard-wired only to show up at work, do their task and leave with a paycheck/ We're hard-wired to be social creatures
[1970s+; fr the definiteness of an actual wired connection in a computer, as distinct from something depending on a program]
3. By extension, anything that is not modifiable, especially in the sense of customisable to one's particular needs or tastes.