great sorrow, grief, or anguish.

1575–85; heart + break

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World English Dictionary
heartbreak (ˈhɑːtˌbreɪk)
intense and overwhelming grief, esp through disappointment in love

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Example sentences
There may be hidden gems, there may be a lot of heartbreak.
It's all the excitement and heartbreak of soccer condensed into a few anxious
Not every lawyer works heartbreak hours at a large firm, in other words.
Booze also dulls the pain of heartbreak, an essential theme of country music.
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