a malicious, usually petty, desire to harm, annoy, frustrate, or humiliate another person; bitter ill will; malice.
a particular instance of such an attitude or action; grudge.
Obsolete. something that causes vexation; annoyance.
verb (used with object), spited, spiting.
to treat with spite or malice.
to annoy or thwart, out of spite.
to fill with spite; vex; offend.
cut off one's nose to spite one's face. nose ( def 23 ).
in spite of, in disregard or defiance of; notwithstanding; despite: She arrived at school on time in spite of the snowstorm.

1250–1300; Middle English; aphetic variant of despite

spiteless, adjective
unspited, adjective

1. malevolence, maliciousness, rancor, venom, spleen. See grudge. 7. See notwithstanding.
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
spite (spaɪt)
1.  maliciousness involving the desire to harm another; venomous ill will
2.  an instance of such malice; grudge
3.  archaic something that induces vexation
4.  (preposition) in spite of in defiance of; regardless of; notwithstanding
5.  to annoy in order to vent spite
6.  archaic to offend
[C13: variant of despite]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

c.1300, shortened form of despit "malice" (see despite). Corresponding to M.Du. spijt, M.L.G. spyt, M.Swed. spit. Commonly spelled spight c.1575-1700. The verb is attested from c.1400. Phrase in spite of is recorded from c.1400.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Idioms & Phrases

in spite of

Regardless of, in defiance of, as in They kept on in spite of their fears. [c. 1400]

The American Heritage® Dictionary of Idioms by Christine Ammer.
Copyright © 1997. Published by Houghton Mifflin.
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Example sentences
The frame itself contains mechanisms that move the mirror smoothly in spite of
  its heavy weight.
In spite of its seeming advantages, the dinosaur possessed little ability to
  respond to changed conditions.
In spite of his eloquence, the grand steward remains unmoved.
But in spite of the absence of definite organization, there was essential unity
  of belief among the dissenters.
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