not sane; not of sound mind; mentally deranged.
of, pertaining to, or characteristic of a person who is mentally deranged: insane actions; an insane asylum.
utterly senseless: an insane plan.

1550–60; < Latin insānus. See in-3, sane

insanely, adverb
insaneness, noun
pseudoinsane, adjective

1. demented; lunatic, crazed, crazy; maniacal. 3. foolish, irrational. See mad. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
insane (ɪnˈseɪn)
1.  a.  mentally deranged; crazy; of unsound mind
 b.  (as collective noun; preceded by the): the insane
2.  characteristic of a person of unsound mind: an insane stare
3.  irresponsible; very foolish; stupid

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1560, from L. insanus "mad, insane, outrageous, excessive, extravagant," from in- "not" + sanus (see sane). Originally only of persons; of actions, from 1842. Cf. lunatic; and It. pazzo "insane," originally a euphemism, from L. patiens "suffering."
Ger. verrückt, lit. pp. of verrücken "to displace," "applied to the brain as to a clock that is 'out of order' " [Buck].
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

insane in·sane (ĭn-sān')
Of, exhibiting, or afflicted with insanity.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Their entire life, it appears to me, is one insanely committed camping trip.
Malpractice insurance for doctors is insanely high and grows each year.
The people pushing for deregulation knew it would make them insanely rich at
  the expense of everyone else.
Heath care costs have become insanely high because the industrialization of
  medicine has ruined the doctor-patient relationship.
Related Words
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