involutional melancholia

noun Psychiatry.
(formerly) extreme depression related to menopause or, less frequently, the male climacteric.

1905–10 Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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American Heritage
Medical Dictionary

involutional melancholia n.
A form of depression that occurs in late middle age, sometimes accompanied by paranoia.

The American Heritage® Stedman's Medical Dictionary
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