ligase

ligase

[lahy-geys, -geyz]
noun Biochemistry.
any of a class of enzymes that catalyze the joining of two molecules by formation of a covalent bond accompanied by the hydrolysis of ATP.

Origin:
1961; < Latin lig(āre) to tie, bind + -ase

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World English Dictionary
ligase (ˈlaɪˌɡeɪz)
 
n
any of a class of enzymes that catalyse the formation of covalent bonds and are important in the synthesis and repair of biological molecules, such as DNA

Collins English Dictionary - Complete & Unabridged 10th Edition
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American Heritage
Medical Dictionary

ligase li·gase (lī'gās', -gāz')
n.
Any of a class of enzymes, including the carboxylases, that catalyze the linkage of two molecules, generally utilizing ATP as the energy donor. Also called synthetase.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Encyclopedia Britannica
Encyclopedia

ligase

any one of a class of about 50 enzymes that catalyze reactions involving the conservation of chemical energy and provide a couple between energy-demanding synthetic processes and energy-yielding breakdown reactions. They catalyze the joining of two molecules, deriving the needed energy from the cleavage of an energy-rich phosphate bond (in many cases, by the simultaneous conversion of adenosine triphosphate [ATP] to adenosine diphosphate [ADP]). A ligase catalyzing the formation of a carbon-oxygen bond between an amino acid and transfer RNA is called amino acid-RNA ligase. Carbon-nitrogen (CN) bonds are formed by the action of such enzymes as amide synthetases and peptide synthetases.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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