[luh-bot-uh-mee, loh-]
noun, plural lobotomies. Surgery.
the operation of cutting into a lobe, as of the brain or the lung.
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World English Dictionary
lobotomy (ləʊˈbɒtəmɪ)
n , pl -mies
1.  a surgical incision into a lobe of any organ
2.  Also called: prefrontal leucotomy a surgical interruption of one or more nerve tracts in the frontal lobe of the brain: used in the treatment of intractable mental disorders
[C20: from lobe + -tomy]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1936, coined from lobe (in the brain sense) + medical suffix -tomy, from Gk. tome "a cutting," from temnein "to cut" (see tome). Fig. use is attested from 1953.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

lobotomy lo·bot·o·my (lə-bŏt'ə-mē, lō-)

  1. Incision into a lobe.

  2. The division of one or more nerve tracts in a lobe of the cerebrum.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
lobotomy   (lə-bŏt'ə-mē)  Pronunciation Key 
Surgical incision into the frontal lobe of the brain to sever one or more nerve tracts, a technique formerly used to treat certain psychiatric disorders but now rarely performed.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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American Heritage
Cultural Dictionary
lobotomy [(luh-bot-uh-mee, loh-bot-uh-mee)]

A surgical incision into one or more of the nerve masses in the front of the brain. A lobotomy may be performed for the relief of certain mental disorders, although it has been largely abandoned in favor of less radical treatments.

Note: Because people who have had a lobotomy often become quite passive after the operation, the term is often used to refer to someone who shows a lack of response or reaction: “She was so tired she just sat there as if she had been lobotomized.”
The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Computing Dictionary

lobotomy definition

1. What a hacker subjected to formal management training is said to have undergone. At IBM and elsewhere this term is used by both hackers and low-level management; the latter doubtless intend it as a joke.
2. The act of removing the processor from a microcomputer in order to replace or upgrade it. Some very cheap clone systems are sold in "lobotomised" form - everything but the brain.
[Jargon File]

The Free On-line Dictionary of Computing, © Denis Howe 2010 http://foldoc.org
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Example sentences
Kearns's book, she was also given a lobotomy upon orders of her father.
It went though the frontal lobes of his brain and gave him the equivalent of a
  frontal lobotomy.
As far as he or anyone else can determine, he has made the first full-length
  feature film in which the chief subject is lobotomy.
While lobotomy has been abandoned, electroshock therapy is still used to treat
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