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loco

 [loh-koh]   Origin

lo·co

   [loh-koh] noun, plural -cos, verb, -coed, -co·ing, adjective
noun
1.
locoweed.
2.
Slang. an insane person; maniac.
3.
Veterinary Pathology. locoism.
verb (used with object)
4.
to poison with locoweed.
5.
Slang. to cause to be insane or crazy.

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adjective
6.
Slang. out of one's mind; insane; crazy.
Origin:
1835–45, Americanism; < Spanish: insane
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2012.
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Collins
World English Dictionary
loco1 (ˈləʊkəʊ)
 
—n
informal short for locomotive

loco2 (ˈləʊkəʊ)
 
—adj
1.  slang chiefly (US) insane
2.  (of an animal) affected with loco disease
 
—n , -cos
3.  short for locoweed
 
—vb
4.  to poison with locoweed
5.  slang (US) to make insane
 
[C19: via Mexican Spanish from Spanish: crazy]

loco3 (ˈləʊkəʊ)
 
—adj
denoting a price for goods, esp goods to be exported, that are in a place specified or known, the buyer being responsible for all transport charges from that place: loco Bristol; a loco price
 
[C20: from Latin locō from a place]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Etymonline
Word Origin & History

loco
1844, Amer.Eng., from Sp. loco (adj.) "insane," of uncertain origin, perhaps from Arabic lauqa, fem. of 'alwaq "fool, crazy person." Loco-weed (1879) was name given to species of western U.S. plants that cause cattle and horse diseases that make them stagger and act strangely.
Online Etymology Dictionary, © 2010 Douglas Harper
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Slang Dictionary

loco definition

[ˈloko]
  1. mod.
    crazy. (From Spanish.) : Who is that loco kid jumping up and down in the front seat?
Dictionary of American Slang and Colloquial Expressions by Richard A. Spears.Fourth Edition.
Copyright 2007. Published by McGraw Hill.
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