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macromutation

[mak-roh-myoo-tey-shuh n] /ˌmæk roʊ myuˈteɪ ʃən/
noun, Genetics.
1.
a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.
Origin of macromutation
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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