the original text of an author's work, handwritten or now usually typed, that is submitted to a publisher.
any text not printed.
a book or document written before the invention of printing.
writing, as distinguished from print.
handwritten or typed, not professionally printed.

1590–1600; < Medieval Latin manūscrīptus written by hand, equivalent to Latin manū by hand (ablative of manus) + scrīptus written; see script

manuscriptal, adjective Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
manuscript (ˈmænjʊˌskrɪpt)
1.  a book or other document written by hand
2.  the original handwritten or typed version of a book, article, etc, as submitted by an author for publication
3.  a.  handwriting, as opposed to printing
 b.  (as modifier): a manuscript document
[C16: from Medieval Latin manūscriptus, from Latin manus hand + scribere to write]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1597, from M.L. manuscriptum, from L. manu scriptus "written by hand," from manu, abl. of manus "hand" (see manual) + scriptus, pp. of scribere "to write" (see script). Abbreviation is MS, plural MSS.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
It's lighter than a regular book, and easier to turn the pages than with a manuscript.
When you saved that unpublished manuscript on them, you figured it would be
  accessible forever.
More than two dozen publishers turned the manuscript down.
The percentage that escaped has intrigued manuscript scholars for decades.
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