Anthropology,Archaeology. the area extending approximately from central Mexico to Honduras and Nicaragua in which diverse pre-Columbian civilizations flourished.
Mes·o·a·mer·i·ca (měz'ō-ə-měr'ĭ-kə, měs'-) A region extending south and east from central Mexico to include parts of Guatemala, Belize, Honduras, and Nicaragua. In pre-Columbian times it was inhabited by diverse civilizations, including the Mayan and the Olmec. Mes'o·a·mer'i·can adj. & n.