methotrexate

[meth-oh-trek-seyt]
noun Pharmacology.
a toxic folic acid analogue, C 2 0 H 2 2 N 8 O 5 , that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.

Origin:
1950–55; metho(xy)- + trexate, of unclear derivation

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World English Dictionary
methotrexate (ˌmɛθəʊˈtrɛkseɪt, ˌmiːθəʊ-)
 
n
an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5

Collins English Dictionary - Complete & Unabridged 10th Edition
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American Heritage
Science Dictionary
methotrexate   (měth'ə-trěk'sāt)  Pronunciation Key 
A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C20H22N8O5.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Encyclopedia Britannica
Encyclopedia

methotrexate

drug used to slow the growth of certain cancers, including leukemia, breast cancer, and lung cancer. It is also used in the treatment of rheumatoid arthritis and psoriasis, a skin disease in which abnormally rapid proliferation of epidermal cells occurs. Methotrexate is an antimetabolite of the B vitamin folic acid (folate). It prevents the synthesis of nucleic acids and thus inhibits cell reproduction. This property also makes it effective as an agent of medical abortion, either for the termination of ectopic pregnancy or of normal intrauterine pregnancy during the first seven to nine weeks.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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Example sentences
These medicines include corticosteroids, cyclosporine, and methotrexate.
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