[mis-chans, -chahns]
a mishap or misfortune.

1250–1300; mis-1 + chance; replacing Middle English mescheance < Old French

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World English Dictionary
mischance (mɪsˈtʃɑːns)
1.  bad luck
2.  a stroke of bad luck

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

c.1300, from O.Fr. meschance, from V.L. *minuscadentiam; see mis- (2) + chance. Now usually "bad luck;" formerly much stronger: "calamity, disaster."
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
The safeguards of these items are all designed to prevent elevator movement when it should not or when a mischance occurs.
By some mischance he was caught by a falling tree, his neck was broken, and he was mangled almost beyond recognition.
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