adverse fortune; bad luck.
an instance of this; mischance; mishap.

1400–50; late Middle English. See mis-1, fortune

2. accident; disaster, calamity, catastrophe; reverse; blow. See affliction.
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
misfortune (mɪsˈfɔːtʃən)
1.  evil fortune; bad luck
2.  an unfortunate or disastrous event; calamity

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

c.1500, from mis- (1) + fortune. Related: Misfortunate.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Some or all of the food purchased with those benefits was destroyed due to a household misfortune or natural disaster.
What these ancient tragedies enact over and over again is not misfortune
  outside a character's control.
Then there were the musicians, dancers, and sculptors who had the misfortune of
  being ensnared on a college campus.
To lose a cabinet appointee may be regarded as a misfortune.
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