mis·for·tune

[mis-fawr-chuhn]
noun
1.
adverse fortune; bad luck.
2.
an instance of this; mischance; mishap.

Origin:
1400–50; late Middle English. See mis-1, fortune


2. accident; disaster, calamity, catastrophe; reverse; blow. See affliction.
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2013.
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Collins
World English Dictionary
misfortune (mɪsˈfɔːtʃən) [Click for IPA pronunciation guide]
 
n
1.  evil fortune; bad luck
2.  an unfortunate or disastrous event; calamity

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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00:10
Misfortune is always a great word to know.
So is quincunx. Does it mean:
a printed punctuation mark (‽), available only in some typefaces, designed to combine the question mark (?) and the exclamation point (!), indicating a mixture of query and interjection, as after a rhetorical question.
an arrangement of five objects, as trees, in a square or rectangle, one at each corner and one in the middle.
Etymonline
Word Origin & History

misfortune
c.1500, from mis- (1) + fortune. Related: Misfortunate.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Some or all of the food purchased with those benefits was destroyed due to a
  household misfortune or natural disaster.
As a result they endured even traumatic misfortune without seeking professional
  help.
The sad human characteristic this article identifies is our penchant to profit
  from misfortune.
Being underestimated is, for some people, a misfortune.
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