mon·o·nu·cle·o·sis

[mon-uh-noo-klee-oh-sis, -nyoo-]
noun Pathology.
1.
the presence of an abnormally large number of mononuclear leukocytes, or monocytes, in the blood.
2.
infectious mononucleosis.
Origin:
1915–20; mononucle(ar) + -osis

Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2013.
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Collins
World English Dictionary
mononucleosis (ˌmɒnəʊˌnjuːklɪˈəʊsɪs) [Click for IPA pronunciation guide]
 
—n
1.  pathol the presence of a large number of monocytes in the blood
2.  See infectious mononucleosis

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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00:10
Mononucleosis has a plethora of syllables.
So is supercalifragilisticexpialidocious. Does it mean:
opposition to the withdrawal of state support or recognition from an established church, esp. the Anglican Church in 19th-century England.
(used as a nonsense word by children to express approval or to represent the longest word in English.)
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Etymonline
Word Origin & History

mononucleosis
1920, coined from mononuclear (1886) + L. -osis "abnormal condition."
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

mononucleosis mon·o·nu·cle·o·sis (mŏn'ō-n&oomacr;'klē-ō'sĭs, -ny&oomacr;-)
n.

  1. Abnormally large numbers of mononuclear white blood cells in the blood, especially forms that are not normal.

  2. Infectious mononucleosis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
mononucleosis   (mŏn'ō-n'klē-ō'sĭs)  Pronunciation Key 
A common infectious disease usually affecting young people, caused by the Epstein-Barr virus and characterized by fever, sore throat, swollen lymph nodes, and fatigue. The symptoms may last for several weeks.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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American Heritage
Cultural Dictionary
mononucleosis [(mon-uh-nooh-klee-oh-sis)]

An acute and infectious disease caused by a virus; its symptoms include fever, swelling of the lymph nodes, and general exhaustion. Mononucleosis gets its name from the kind of white blood cell (monocyte) that increases in number in the blood of persons who have the disease. There is no specific treatment, but sufferers usually recover within a few weeks.

Note: Mononucleosis is sometimes called the “kissing disease,” because at one time the virus was thought to be transmitted by kissing. The virus can be found in the saliva of those who have the disease, so there may be some truth in the belief.
The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Example sentences
For a sore throat caused by infectious mononucleosis, rest and home treatment is recommended.
For example, you may feel weak if you have an infection such as mononucleosis or the flu.
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