noun Slang.
vigor; verve; pep.
courage and aggressiveness; nerve.
skill; know-how.

1925–30, Americanism; after Moxie, a trademark (name of a soft drink) Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
moxie (ˈmɒksɪ)
slang (US), (Canadian) courage, nerve, or vigour
[from the trademark Moxie, a soft drink]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

1908, popularized by Moxie, trademark name registered 1924 for a bitter non-alcoholic beverage; the word was used as far back as 1876 as the name of a patent medicine advertised to "build up your nerve," and it is perhaps ultimately from a New England Indian word.
Online Etymology Dictionary, © 2010 Douglas Harper
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Computing Dictionary

Moxie definition

language, music
A language for real-time computer music synthesis, written in XPL.
["Moxie: A Language for Computer Music Performance", D. Collinge, Proc Intl Computer Music Conf, Computer Music Assoc 1984, pp.217-220].

The Free On-line Dictionary of Computing, © Denis Howe 2010
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Example sentences
Of course, it takes a certain amount of moxie or youthful insouciance to
  actually make the look work.
The girl has moxie, you gotta give her that.
The son of a shop teacher, he had the woodcrafting moxie to build his own track.
My theory is that the rider's cowboy hat contributes mightily to the judges'
  impression of the animal's moxie.
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