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[noo r-oh-fahy-broh-muh-toh-sis, nyoo r-] /ˌnʊər oʊ faɪˌbroʊ məˈtoʊ sɪs, ˌnyʊər-/
noun, Pathology
a dominantly inherited genetic disorder characterized by flat brown patches on the skin, neurofibromas of the skin and internal organs, and in some cases skeletal deformity.
1895-1900; < New Latin neurofibromat-, stem of neurofibroma neurofibroma + -osis Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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British Dictionary definitions for neurofibromatosis


a condition characterized by the formation of benign tumours on the fibrous coverings of the peripheral nerves and the development of areas of café-au-lait spots
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
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neurofibromatosis in Medicine

neurofibromatosis neu·ro·fi·bro·ma·to·sis (nur'ō-fī-brō'mə-tō'sĭs, nyur'-)
A genetic disease characterized by pigmented skin lesions and multiple skin neurofibromas, and sometimes accompanied by physical deformity and a predisposition to brain tumors and various forms of cancer. Also called multiple neurofibroma, neuromatosis, Recklinghausen's disease, von Recklinghausen's disease.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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neurofibromatosis in Science
A genetic disease characterized by multiple benign tumors of peripheral nerves, called neurofibromas, and pigmented spots on the skin, sometimes accompanied by bone deformity and a predisposition to cancers, especially of the brain.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Encyclopedia Article for neurofibromatosis

either of two hereditary disorders characterized by distinctive skin lesions and by benign, progressively enlarging tumours of the nervous system. Neurofibromatosis type 1, also known as von Recklinghausen's disease, is much the more common of the two disorders and is present in about one of every 3,000 live births. This type is characterized by the presence of cafe-au-lait (pale brown) spots on the skin and the formation of numerous benign soft tumours arising from the abnormal growth of nerves. The cafe-au-lait spots may be present at birth or infancy, and the neurofibromas and other tumours appear in late childhood or early adulthood; the latter can sometimes result in grossly disfiguring effects owing to their large size. The course of the disease is progressive in most cases. Neurofibromatosis type 2 is a much rarer inherited disease marked by tumours of the auditory canal in the ear and by small numbers of cafe-au-lait spots.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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