[nik-uh-teen, -tin, nik-uh-teen]
noun Chemistry.
a colorless, oily, water-soluble, highly toxic, liquid alkaloid, C 1 0 H 1 4 N 2 , found in tobacco and valued as an insecticide.

1810–20; < French; see nicotiana, -ine2

nicotined, adjective
nicotineless, adjective Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
nicotine (ˈnɪkəˌtiːn)
a colourless oily acrid toxic liquid that turns yellowish-brown in air and light: the principal alkaloid in tobacco, used as an agricultural insecticide. Formula: C10H14N2
[C19: from French, from New Latin herba nicotiana Nicot's plant, named after J. Nicot (1530--1600), French diplomat who introduced tobacco into France]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

"poisonous alkaloid found in tobacco leaves," 1819, from Fr. nicotine, from Mod.L. Nicotiana, formal botanical name for the tobacco plant, named for Jean Nicot (c.1530-1600), Fr. ambassador to Portugal, who sent tobacco seeds and powdered leaves back to France 1561. His name is a dim. of Nicolas.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

nicotine nic·o·tine (nĭk'ə-tēn')
A colorless, poisonous alkaloid derived from the tobacco plant and used as an insecticide. It is the substance in tobacco to which smokers can become addicted.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
nicotine   (nĭk'ə-tēn')  Pronunciation Key 
A colorless, poisonous compound occurring naturally in the tobacco plant. It is used in medicine and as an insecticide, and it is the substance in tobacco products to which smokers can become addicted. Nicotine is an alkaloid. Chemical formula: C10H14N2.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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American Heritage
Cultural Dictionary
nicotine [(nik-uh-teen)]

A poisonous chemical substance found in the tobacco plant.

The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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Example sentences
But in an age before nicotine patches and gums to aid in kicking the habit,
  one's options to stop smoking were somewhat limited.
Nicotine alone, however, is hardly a reason to worry.
Of course, those who find relief from stress through cigarettes are feeling the
  effect of nicotine.
They receive the same amount of nicotine as from cigarettes and are at equal
  risk of addiction.
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