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1908, from German nucleotid (1908), from nucleo-, modern comb. form of Latin nucleus (see nucleus) + -ide, with -t- for the sake of euphony.
nucleotide nu·cle·o·tide (nōō'klē-ə-tīd', nyōō'-)n. Any of various compounds consisting of a nucleoside combined with a phosphate group and forming the basic constituent of DNA and RNA.