a combining form meaning “old” or “ancient,” especially in reference to former geologic time periods, used in the formation of compound words: paleobotany.
Also, pale-, especially British, palae-, palaeo-.

< Greek palaio-, combining form of palaiós Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
paleo- or (before a vowel) pale-
combining form
variants (esp US) of palaeo-
pale- or (before a vowel) pale-
combining form

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

prefix used in scientific combinations (mostly since c.1870), from Gk. palaio-, comb. form of palaios "old, ancient," from palai "long ago, far back," related to palin "again, backwards," tele- "far off, at a distance," from PIE base *kwel- "to turn, move about," also "far" (in space and time); see
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

paleo- or pale-

  1. Ancient; prehistoric; old: paleopathology.

  2. Early; primitive: paleokinetic.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
A prefix that means "prehistoric" (as in paleontology) or "early or primitive" (as in Paleolithic).
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Example sentences
They need to study a group that doesn't eat any starches, ie the paleo dieters.
Paleo hunters pursued bighorn sheep and deer and left split-twig figurines in caves.
If you think that one could do better with paleo data, then you're fooling yourself.
Paleo-Indians moved into the northern forest not long after the glaciers receded.
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