n. [a] pain in the ass. (Initialism. A computer abbreviation, not pronounced.) : The SYSOP here is a real PITA. I wish he would leave us alone.
Dictionary of American Slang and Colloquial Expressions by Richard A. Spears.Fourth Edition. Copyright 2007. Published by McGraw Hill.
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Word Origin & History
pita
"thick, flat bread," 1951, from Modern Heb. pita or Modern Gk. petta "bread," perhaps from Gk. peptos "cooked," or somehow connected to pizza (q.v.).