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city, seat of Dutchess county, eastern New York, U.S. It lies on the east bank of the Hudson River (there bridged to Highland), 75 miles (121 km) north of New York City. It was settled by the Dutch in 1683; its name, of Wappinger Indian origin, means "reed-covered lodge by the little water place." Poughkeepsie served as the temporary state capital, and the U.S. Constitution was ratified there in 1788. Its importance as a river grain port declined after completion of the Erie Canal in 1825, and the city became a manufacturing and commercial centre. The Smith Brothers (William and Andrew, the nationally advertised bearded "Trade" and "Mark") made their first cough drops about 1850 in Poughkeepsie. Industry now includes computer assembly and research, printing and lithography, and the production of swimming pool equipment, electronic devices, chemicals, and ball bearings.