| 1. | Biochemistry. a hormone, C2 1H3 0O2, that prepares the uterus for the fertilized ovum and maintains pregnancy. |
| 2. | Pharmacology. a commercial form of this compound, obtained from the corpus luteum of pregnant sows or synthesized: used in the treatment of dysfunctional uterine bleeding, dysmenorrhea, threatened or recurrent abortion, etc. |

progesterone pro·ges·ter·one (prō-jěs'tə-rōn')
n.
A steroid hormone secreted by the corpus luteum and by the placenta, that acts to prepare the uterus for implantation of the fertilized ovum, to maintain pregnancy, and to promote development of the mammary glands. Also called corpus luteum hormone, luteohormone, progestational hormone.
A drug prepared from natural or synthetic progesterone, used for the prevention of miscarriage and the treatment of menstrual disorders.