psychoactive

[sahy-koh-ak-tiv]
adjective
of or pertaining to a substance having a profound or significant effect on mental processes: a psychoactive drug.

Origin:
1960–65; psycho- + active

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Collins
World English Dictionary
psychoactive (ˌsaɪkəʊˈæktɪv)
 
adj
capable of affecting mental activity: a psychoactive drug

Collins English Dictionary - Complete & Unabridged 10th Edition
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American Heritage
Medical Dictionary

psychoactive psy·cho·ac·tive (sī'kō-āk'tĭv)
adj.
Affecting the mind or mental processes. Used of a drug.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Tobacco is considered to be a mood and behavior altering substance that is
  psychoactive and abusable.
It's not really practical to go out in public while under the influence of
  psychoactive drugs.
Compared to alcohol, caffeine is on the other end of the spectrum of
  psychoactive drugs in that it is a stimulant.
Caffeine, a psychoactive drug used by nearly everybody, alters human
  neurochemistry.
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