1541, "branch out," from M.Fr.
ramifier (1314), from M.L.
ramificare, from L.
ramus "branch" (related to
radix "root;" see
radish) + root of
facere "to make" (see
factitious).
Ramification in literal sense is first recorded 1677, from Fr.; transf. sense of "outgrowth, consequence" first recorded 1755.