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[skli-roh-sis] /sklɪˈroʊ sɪs/
noun, plural scleroses
[skli-roh-seez] /sklɪˈroʊ siz/ (Show IPA)
Pathology. a hardening or induration of a tissue or part, or an increase of connective tissue or the like at the expense of more active tissue.
Botany. a hardening of a tissue or cell wall by thickening or lignification.
Origin of sclerosis
1350-1400; Middle English < Medieval Latin < Greek sklḗrōsis hardening. See scler-, -osis
Related forms
sclerosal, adjective Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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British Dictionary definitions for sclerosis


noun (pl) -ses (-siːz)
(pathol) a hardening or thickening of organs, tissues, or vessels from chronic inflammation, abnormal growth of fibrous tissue, or degeneration of the myelin sheath of nerve fibres, or (esp on the inner walls of arteries) deposition of fatty plaques Compare arteriosclerosis, atherosclerosis, multiple sclerosis
the hardening of a plant cell wall or tissue by the deposition of lignin
a debilitating lack of progress or innovation within an institution or organization
Derived Forms
sclerosal, adjective
Word Origin
C14: via Medieval Latin from Greek sklērōsis a hardening
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word Origin and History for sclerosis

"morbid hardening of the tissue," late 14c., from Medieval Latin sclirosis "a hardness, hard tumor," from Greek sklerosis "hardening," from skleros "hard" (see sclero-). Figurative use by 1954.

Online Etymology Dictionary, © 2010 Douglas Harper
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sclerosis in Medicine

sclerosis scle·ro·sis (sklə-rō'sĭs)
n. pl. scle·ro·ses (-sēz)

  1. The hardening of a tissue or part due to chronic inflammation.

  2. A thickening or hardening of a body part or system especially from excessive formation of fibrous interstitial or glial tissue.

  3. Any of various diseases characterized by thickening or hardening, such as arteriosclerosis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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