noun, plural scleroses [skli-roh-seez] .
Pathology. a hardening or induration of a tissue or part, or an increase of connective tissue or the like at the expense of more active tissue.
Botany. a hardening of a tissue or cell wall by thickening or lignification.

1350–1400; Middle English < Medieval Latin < Greek sklḗrōsis hardening. See scler-, -osis

sclerosal, adjective Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
sclerosis (sklɪəˈrəʊsɪs)
n , pl -ses
1.  pathol arteriosclerosis atherosclerosis Compare multiple sclerosis a hardening or thickening of organs, tissues, or vessels from chronic inflammation, abnormal growth of fibrous tissue, or degeneration of the myelin sheath of nerve fibres, or (esp on the inner walls of arteries) deposition of fatty plaques
2.  the hardening of a plant cell wall or tissue by the deposition of lignin
3.  a debilitating lack of progress or innovation within an institution or organization
[C14: via Medieval Latin from Greek sklērōsis a hardening]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

"morbid hardening of the tissue," late 14c., from M.L. sclirosis "a hardness, hard tumor," from Gk. sklerosis "hardening," from skleros "hard," related to skellein "to dry up, parch," from PIE *skle-ro-, from base *skele- "to parch, wither."
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

sclerosis scle·ro·sis (sklə-rō'sĭs)
n. pl. scle·ro·ses (-sēz)

  1. The hardening of a tissue or part due to chronic inflammation.

  2. A thickening or hardening of a body part or system especially from excessive formation of fibrous interstitial or glial tissue.

  3. Any of various diseases characterized by thickening or hardening, such as arteriosclerosis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
Researchers have identified two types of white blood cells that are thought to
  cause multiple sclerosis by attacking nerve tissue.
The danger is that over time, without another bout of reform, sclerosis will
  set in.
In fact, the substance could possibly aid in the treatment of depression and
  multiple sclerosis.
Twin study surveys genome for cause of multiple sclerosis.
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