shake-up

[sheyk-uhp]
noun
a thorough change in a business, department, or the like, as by dismissals, demotions, etc.

Origin:
1900–05; noun use of verb phrase shake up

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Based on the Random House Dictionary, © Random House, Inc. 2014.
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WordNet
shake-up

noun
the imposition of a new organization; organizing differently (often involving extensive and drastic changes); "a committee was appointed to oversee the reorganization of the curriculum"; "top officials were forced out in the cabinet shakeup" [syn: reorganization
WordNet® 3.0, © 2006 by Princeton University.
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Example sentences
Unfamiliar dinosaurs also have their role to play in this shake-up.
The plan promises to be the biggest shake-up of the space program since the
  glory days of the moon landings.
So suddenly a shake-up of the system for applying to university is once again
  proposed, this time by the body concerned.
The details of the shake-up are not known, except to company insiders.
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