| a chronic infectious disease, caused by a spirochete, Treponema pallidum, usually venereal in origin but often congenital, and affecting almost any organ or tissue in the body, esp. the genitals, skin, mucous membranes, aorta, brain, liver, bones, and nerves. |

A sexually transmitted disease caused by a microorganism. In its initial stages (called primary syphilis), it is manifested by a skin ulcer called a chancre. If the disease is not treated by penicillin or other antibiotics, the infection becomes chronic. In so-called tertiary syphilis, virtually any tissue in the body can be damaged, including the cardiovascular and nervous systems. The disease, if left untreated, can cause blindness, mental illness, and death.
syphilis syph·i·lis (sĭf'ə-lĭs)
n.
A chronic infectious disease caused by Treponema pallidum, either transmitted by direct contact, usually in sexual intercourse, or passed from mother to child in utero, and progressing through three stages characterized respectively by local formation of chancres, ulcerous skin eruptions, and systemic infection that leads to general paresis.