thoroughfare

[thur-oh-fair, -uh-fair, thuhr-]
noun
1.
a road, street, or the like, that leads at each end into another street.
2.
a major road or highway.
3.
a passage or way through: no thoroughfare.
4.
a strait, river, or the like, affording passage.

Origin:
1350–1400; Middle English thurghfare. See thorough, fare

Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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Collins
World English Dictionary
thoroughfare (ˈθʌrəˌfɛə)
 
n
1.  a road from one place to another, esp a main road
2.  way through or access: no thoroughfare

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Etymonline
Word Origin & History

thoroughfare
late 14c., "passage or way through," from thorough + fare.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Located at the center of bustling downtown on the main pedestrian thoroughfare.
The populace lines up on the main thoroughfare to watch hours of marching bands, homemade floats and home-crowned royalty.
However small the protesters' number, they end up bringing traffic to a halt
  all around the city's main thoroughfare.
Buggies and wagons almost filled the narrow thoroughfare.
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