"You canker blossom!" 3 Shakespearean Insults
1849, probably via South African Dutch, from a Bantu language (cf. Setswana tsetse. Luyia tsiisi "flies").
tsetse fly tset·se fly or tzet·ze fly (tsět'sē, tsē'tsē)
Any of several two-winged bloodsucking African flies of the genus Glossina, often carrying and transmitting pathogenic trypanosomes to humans and livestock.