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for historical evolution, see V. Used punningly for you by 1588 ["Love's Labour's Lost," V.i.60], not long after the pronunciation shift that made the vowel a homonym of the pronoun. As a simple shorthand (without intentional word-play), it is recorded from 1862. Common in business abbreviations since 1923 (e.g. U-Haul, attested from 1951).
The symbol for the element uranium.
A heavy, silvery-white, highly toxic, radioactive metallic element of the actinide series. It has 14 known isotopes, of which U 238 is the most naturally abundant, occurring in several minerals. Fissionable isotopes, especially U 235, are used in nuclear reactors and nuclear weapons. Atomic number 92; atomic weight 238.03; melting point 1,132°C; boiling point 3,818°C; specific gravity 18.95; valence 2, 3, 4, 5, 6. See Periodic Table.