a change or variation occurring in the course of something.
2.
interchange or alternation, as of states or things.
3.
vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs: They remained friends through the vicissitudes of 40 years.
4.
regular change or succession of one state or thing to another.
Origin: 1560–70; < Latinvicissitūdō, equivalent to viciss(im) in turn (perhaps by syncope < *vice-cessim; vice in the place of (see vice3) + cessim giving way, adv. derivative of cēdere to go, proceed) + -i--i--tūdō-tude
a calculus or concretion found in the stomach or intestines of certain animals, esp. ruminants, formerly reputed to be an effective remedy for poison.
a printed punctuation mark (‽), available only in some typefaces, designed to combine the question mark (?) and the exclamation point (!), indicating a mixture of query and interjection, as after a rhetorical question.
a children's mummer's parade, as on the Fourth of July, with prizes for the best costumes.
an arrangement of five objects, as trees, in a square or rectangle, one at each corner and one in the middle.
1560s, from M.Fr. vicissitude (14c.), from L. vicissitudinem (nom. vicissitudo) "change," from vicissim "changeably, in turn," from vicis "a turn, change" (see vicarious). Related: Vicissitudes.