"You canker blossom!" 3 Shakespearean Insults
Old English wrist, from Proto-Germanic *wristiz (cf. Old Norse rist "instep," Old Frisian wrist, Middle Dutch wrist, German Rist "back of the hand, instep"), from Proto-Germanic *wrig-, *wreik- "to turn" (see wry). The notion is "the turning joint."
The joint between the hand and the forearm.