verb (used with object)
to distress with mental or bodily pain; trouble greatly or grievously: to be afflicted with arthritis.
to overthrow; defeat.
to humble.

1350–1400; Middle English afflicten < Latin afflīctus distressed, past participle of afflīgere to cast down (af- af- + flīg- knock + -tus past participle suffix); replacing Middle English aflight < Middle French aflit < L. See inflict

afflictedness, noun
afflicter, noun
overafflict, verb (used with object)
preafflict, verb (used with object)
self-afflicting, adjective
unafflicted, adjective
unafflictedly, adverb
unafflictedness, noun
unafflicting, adjective

afflict, infect, inflict.

1. vex, harass, torment, plague. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
afflict (əˈflɪkt)
(tr) to cause suffering or unhappiness to; distress greatly
[C14: from Latin afflictus, past participle of afflīgere to knock against, from flīgere to knock, to strike]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

late 14c., "to cast down," from O.Fr. afflicter, from L. afflictare "to damage, harass, torment," freq. of affligere (pp. afflictus) "to dash down, overthrow," from ad- "to" + fligere (pp. flictus) "to strike," from PIE base *bhlig- "to strike" (cf. Gk. phlibein "to press, crush," Czech blizna "scar,"
Welsh blif "catapult"). Transf. meaning of "trouble, distress," is first recorded 1530s.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Healing the afflicted is not merely a matter of compassion.
The afflicted were offered small stipends to confine themselves to the containment center, preventing further contamination.
But oxygen levels are unusually low, and run especially deep, in the afflicted area.
This novel's central figure is a woman ostensibly afflicted with hyperthymia
  — an excess of happiness.
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