verb (used with object)
to cause pain, uneasiness, or trouble to.
verb (used without object)
to be unwell; feel pain; be ill: He's been ailing for some time.

before 950; Middle English ail, eilen, Old English eglan to afflict (cognate with Middle Low German egelen annoy, Gothic -agljan), derivative of egle painful; akin to Gothic agls shameful, Sanskrit aghám evil, pain

ale, ail, awl.

1. bother, annoy, distress. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
ail (eɪl)
1.  (tr) to trouble; afflict
2.  (intr) to feel unwell
[Old English eglan to trouble, from egle troublesome, painful, related to Gothic agls shameful]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

O.E. eglian "to trouble, plague, afflict," from P.Gmc. *azljaz (cf. O.E. egle "hideous, loathsome, troublesome, painful;" Goth. agls "shameful, disgraceful," agliþa "distress, affliction, hardship," us-agljan "to oppress, afflict"), from PIE *agh-lo-, suffixed form of base *agh- "to be depressed,
be afraid." Related: Ailing (c.1600); ailment formed in Eng. 1706.
"It is remarkable, that this word is never used but with some indefinite term, or the word no thing; as What ails him? ... Thus we never say, a fever ails him." [Johnson]
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
While it may soothe your symptoms, licorice more than likely isn't curing what
  ails you.
We will eventually figure out how to solve what ails us, regardless of the
Sounds interesting, but some may depend on what ails you.
In truth, none of the characters in the play want to be cured of what ails them.
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