|a calculus or concretion found in the stomach or intestines of certain animals, esp. ruminants, formerly reputed to be an effective remedy for poison.|
|an arrangement of five objects, as trees, in a square or rectangle, one at each corner and one in the middle.|
|1.||the act or result of amplifying|
|2.||material added to a statement, story, etc, in order to expand or clarify it|
|3.||a statement, story, etc, with such additional material|
|a. the increase in strength of an electrical signal by means of an amplifier|
|b. another word for gain|
|5.||genetics Also called: gene amplification the production of multiple copies of a particular gene or DNA sequence. It can occur naturally or artificially, by genetic engineering techniques|
amplification am·pli·fi·ca·tion (ām'plə-fĭ-kā'shən)
The process of increasing the magnitude of a variable quantity, especially the magnitude of voltage, power, or current, without altering any other quality.
The result of such a process.
gene amplification n.
A cellular process characterized by the production of copies of a gene or genes to amplify the phenotype that the gene confers on the cell.
An increase in the number of copies of a gene in a cell, resulting in an elevation in the level of the RNA or protein encoded for by the gene and a corresponding amplification of the phenotype that the gene confers on the cell. Drug resistance in cancer cells is linked to amplification of the gene that prevents absorption of the chemotherapeutic agent by the cell.
A process in a cell by which a particular gene is replicated so that more copies are available to produce a protein for the cell's use. For example, the genes that code for proteins involved in ribosomes are amplified early in the process of cell development so that there are sufficient numbers of them to assemble the cell.
Note: PCR, polymerase chain reaction, can be considered a type of man-made gene amplification process.