"You canker blossom!" 3 Shakespearean Insults
1797, from French antagonisme or directly from late Greek antagonisma, noun of action from antagonizesthai "to struggle against" (see antagonist).
antagonism an·tag·o·nism (ān-tāg'ə-nĭz'əm)n. Mutual opposition in action between structures, agents, diseases, or physiological processes. Also called mutual resistance.