| 1. | loss of hope; hopelessness. |
| 2. | someone or something that causes hopelessness: He is the despair of his mother. |
| 3. | to lose, give up, or be without hope (often fol. by of): to despair of humanity. |
| 4. | Obsolete. to give up hope of. |

de·spair·ing (dĭ-spâr'ĭng) adj. Characterized by or resulting from despair; hopeless. See Synonyms at despondent. de·spair'ing·ly adv. |