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diethylstilbestrol di·eth·yl·stil·bes·trol (dī-ěth'əl-stĭl-bēs'trôl, -trōl)
nonsteroidal synthethic estrogen used as a drug and formerly used to promote growth of livestock. Unlike natural estrogens, DES remains active following oral administration. It is also administered as vaginal suppositories and by injection. DES breaks down more slowly in the body than do the natural estrogens.