direful

[dahyuhr-fuhl]
adjective
1.
dreadful; awful; terrible.
2.
indicating trouble: direful forecasts.

Origin:
1575–85; dire + -ful

direfully, adverb
direfulness, noun
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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WordNet
direful

adjective
causing fear or dread or terror; "the awful war"; "an awful risk"; "dire news"; "a career or vengeance so direful that London was shocked"; "the dread presence of the headmaster"; "polio is no longer the dreaded disease it once was"; "a dreadful storm"; "a fearful howling"; "horrendous explosions shook the city"; "a terrible curse" 
WordNet® 3.0, © 2006 by Princeton University.
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Example sentences
Since then it has gradually failed under the direful work of sin.
The newspapers of the day were filled with accounts of this direful disaster, but there were few survivors to tell the tale.
There is no mystery about the origin of this direful disease.
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