disorient

[dis-awr-ee-ent, -ohr-]
verb (used with object)
1.
to cause to lose one's way: The strange streets disoriented him.
2.
to confuse by removing or obscuring something that has guided a person, group, or culture, as customs, moral standards, etc.: Society has been disoriented by changing values.
3.
Psychiatry. to cause to lose perception of time, place, or one's personal identity.

Origin:
1645–55; < French désorienter, equivalent to dés- dis-1 + orienter to orient

Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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Example sentences
The effects of instability and discord can be truly disorienting.
It can be terribly disorienting in a blizzard that's come from nowhere.
The collision of tradition and modernity in the community can be disorienting.
It can be disorienting and strange to think about retirement when you begin
  your academic career.
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