cartilage, especially in meats.

before 900; Middle English, Old English; cognate with Old Frisian, Middle Low German gristal; akin to Old English grost cartillage Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
gristle (ˈɡrɪsəl)
cartilage, esp when in meat
[Old English gristle; related to Old Frisian, Middle Low German gristel]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

O.E. gristle "cartilage," related to grost "gristle," from a common W.Gmc. word (cf. O.Fris., M.L.G. gristel, O.H.G. crostila).
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Another is to stand on your head and eat a piece of gristle.
Remove skin and gristle from cooked corned beef, then chop the meat.
Other than not eating the fatty gristle on a ribeye, they do not diet.
It consisted of one piece of gristle followed by another.
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