a hormone that is thought to suppress appetite and speed up metabolism.

1995–2000; < Greek leptós small, thin + -in2

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World English Dictionary
leptin (ˈlɛptɪn)
a protein, produced by fat cells in the body, that acts on the brain to regulate the amount of additional fat laid down in the body
[C20: from lepto- + -in]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Dictionary.com's 21st Century Lexicon
Main Entry:  leptin
Part of Speech:  n
Definition:  a protein produced by fat cells and involved in regulating food intake and fat storage in the body
Etymology:  1995-2000; < Gk leptos thin
Dictionary.com's 21st Century Lexicon
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American Heritage
Science Dictionary
leptin   (lěp'tĭn')  Pronunciation Key 
A peptide hormone and neurotransmitter produced by fat cells and involved in the regulation of appetite.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Example sentences
Leptin appears to play an important role in insulin resistance and fat storage
  in the body, but its role in obesity is unclear.
Nor does it promote the production of leptin, a hormone made by fat cells.
The fat-regulating protein leptin was first linked to obesity more than a
  decade ago.
Leptin is a hormone made by fat cells that tells you when you're full.
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